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Statistics in Oncology Series
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- Statistics in Oncology SeriesOpen Access
Biomarker Discovery and Validation: Statistical Considerations
Journal of Thoracic OncologyVol. 16Issue 4p537–545Published online: February 1, 2021- Fang-Shu Ou
- Stefan Michiels
- Yu Shyr
- Alex A. Adjei
- Ann L. Oberg
Cited in Scopus: 30Biomarkers have various applications including disease detection, diagnosis, prognosis, prediction of response to intervention, and disease monitoring. In this era of precision medicine, having validated biomarkers to inform clinical decision making is more important than ever. In this article, we discuss best the practices and potential issues in biomarker discovery and validation. We encourage team science partnerships to bring cutting-edge discovery from bench to bedside, leading to improved patient care and outcomes.