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State of the Art: Concise Review
Open Archive
Ki-67 Antigen in Lung Neuroendocrine Tumors: Unraveling a Role in Clinical Practice
Journal of Thoracic Oncology
Vol. 9Issue 3p273–284Published in issue: March, 2014
- Giuseppe Pelosi
- Guido Rindi
- William D. Travis
- Mauro Papotti
Cited in Scopus: 140
Classification of lung neuroendocrine (NE) tumors is a step-wise process with four tumor categories being identified by morphology, namely typical carcinoid (TC), atypical carcinoid, large-cell NE carcinoma, and small-cell lung carcinoma (SCLC). Ki-67 antigen or protein (henceforth simply Ki-67) has been largely studied in these tumors, but the clinical implications are so far not clear. A well-defined role has regarded the diagnostic use in the separation of TC and AC from SCLC in nonsurgical specimens, with monoclonal antibody MIB-1 resulting in the most used reagent after antigen retrieval procedures.