Editors Choice
Respiratory and Cardiometabolic Comorbidities and Stages I to III NSCLC Survival: A Pooled Analysis From the International Lung Cancer Consortium
We explored the association of respiratory and cardiometabolic comorbidities with NSCLC overall survival (OS) and lung cancer-specific survival (LCSS), by stage, in a large, multicontinent NSCLC pooled data set.Robotic Esophagectomy Compared With Open Esophagectomy Reduces Sarcopenia within the First Postoperative Year: A Propensity Score-Matched Analysis
Sarcopenia is a known risk factor for adverse outcomes after esophageal cancer (EC) surgery. Robot-assisted minimally invasive esophagectomy (RAMIE) offers numerous advantages, including reduced morbidity and mortality. However, no evidence exists to date comparing the development of sarcopenia after RAMIE and open esophagectomy (OE). The objective was to evaluate whether the development of sarcopenia within the first postoperative year after esophagectomy is associated with the surgical approach: RAMIE versus OE.Treatment Characteristics and Real-World Progression-Free Survival in Patients With Unresectable Stage III NSCLC Who Received Durvalumab After Chemoradiotherapy: Findings From the PACIFIC-R Study
The phase 3 PACIFIC trial established consolidation therapy with durvalumab as standard of care for patients with unresectable, stage III NSCLC and no disease progression after definitive chemoradiotherapy (CRT). The observational PACIFIC-R study assesses the real-world effectiveness of durvalumab in patients from an early access program. Here, we report treatment characteristics and a preplanned analysis of real-world progression-free survival (rwPFS).UNcommon EGFR Mutations: International Case Series on Efficacy of Osimertinib in Real-Life Practice in First-LiNe Setting (UNICORN)
Approximately 10% of EGFR mutations (EGFRmuts) are uncommon (ucEGFRmuts). We aimed to collect real-world data about osimertinib for patients with ucEGFRmuts.A Phase 2 Study of Palbociclib for Recurrent or Refractory Advanced Thymic Epithelial Tumors (KCSG LU17-21)
Thymic epithelial tumors (TETs) are rare but are the most common tumors of the anterior mediastinum. Platinum-based combination chemotherapy is the standard of care for such tumors and is associated with a 50% to 90% objective response rate (ORR) in metastatic disease. Nevertheless, there is no standard chemotherapeutic option after failure of platinum-based combination chemotherapy. Genetic alterations associated with the cell cycle, including pRB, p16INK4A, and cyclin D1, are most often observed in TETs.Lung Cancer in Turkey
Turkey stretches from the Balkans to the Middle East and is among the larger countries in terms of land area and population (Fig. 1). Turkey’s population of approximately 85 million people encompasses a diverse genomic, ethnic, and cultural heritage with roots from several empires and civilizations dating back to the Paleolithic age. According to the GLOBOCAN 20201 registry, lung cancer (LC) comprises 17.6% of all cancer types. It ranks highest in Turkey, with 41,000 new cases in 2020 and an age-adjusted incidence rate of 41.7 and 8.7 per 100,000 for men and women, respectively.Lung Cancer in Rwanda
Rwanda is a landlocked country in East Africa with an estimated population of approximately 12.5 million in 2018, making it the second most densely populated country in Africa.1,2 Rwanda is counted among low-income countries, with a little more than 80% of Rwandans living in rural areas. Women represent approximately a half of the population.3 Figure 1 is the map of Rwanda in relation to its neighboring countries.Antiangiogenesis May Not Be a Universal Booster of EGFR Tyrosine Kinase Inhibitors
Since the concept of antiangiogenesis was introduced in oncology, various types of systemic anticancer treatment, from cytotoxic chemotherapy, molecular targeted therapy, to immunotherapy, had been attempted to be combined with antiangiogenic agents. At around 2010, cytotoxic chemotherapy and EGFR tyrosine kinase inhibitors (TKIs) were two pillars of systemic treatments for NSCLC, and the combination of antiangiogenic agents and EGFR TKIs was thus naturally to be explored.Determining Whether YAP1 and POU2F3 Are Antineuroendocrine Factors
Rudin et al.1 reported that SCLCs can be subtyped into four groups (SCLC-A, SCLC-N, SCLC-Y, and SCLC-P) according to four molecules—ASCL1, NEUROD1, POU2F3, and YAP1—based on gene expression data of primary SCLC samples and cell lines. Initially, both YAP1 and POU2F3 were identified as markers of the non-neuroendocrine (non-NE) phenotype of SCLC; however, subsequent studies have gradually revealed that YAP1 and POU2F3 have different significance.EGFR Tyrosine Kinase Inhibitor Sequencing Revisited: From the Revival of Old Tools to the Integration of New Agents
In this issue of the Journal of Thoracic Oncology, Piccirillo et al.1 report the results of the BEVERLY trial, a randomized phase 3 study that reveals the progression-free survival (PFS) benefit of bevacizumab to erlotinib as first-line treatment for Italian patients with metastatic NSCLC with common EGFR mutations. In this large study, after a median follow-up of 36.3 months, median investigator-assessed PFS was 15.4 months with erlotinib plus bevacizumab and 9.6 months with erlotinib alone (hazard ratio = 0.66, 95% confidence interval: 0.47–0.92).Assessment of Updated Commission on Cancer Guidelines for Intraoperative Lymph Node Sampling in Early Stage NSCLC
The American College of Surgeons Commission on Cancer recently updated its sampling recommendations for early stage NSCLC from at least 10 lymph nodes to at least one N1 (hilar) and three N2 (mediastinal) lymph node stations. Nevertheless, intraoperative lymph node sampling minimums remain subject to debate. We sought to evaluate these guidelines in patients with early stage NSCLC.Surgical, Radiation, and Systemic Treatments of Patients With Thymic Epithelial Tumors: A Clinical Practice Guideline
The aim of this guideline was to provide recommendations for the most effective therapy for patients with thymic epithelial tumors, including thymoma, thymic carcinoma, and thymic neuroendocrine tumors (NETs). This guideline is intended to be used by all health care professionals managing patients with thymic epithelial tumors.
