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Crizotinib Effects on Creatinine and Non-Creatinine–Based Measures of Glomerular Filtration Rate
Journal of Thoracic OncologyVol. 9Issue 11p1634–1637Published in issue: November, 2014- D. Ross Camidge
- Evelyn M. Brosnan
- Chamath DeSilva
- Phillip J. Koo
- Michel Chonchol
Cited in Scopus: 19Rapid reductions in creatinine-based estimates of the glomerular filtration rate (GFR) have recently been reported secondary to crizotinib use. Whether these reflect drug-induced changes in the true GFR or the validity of creatinine as a measure of kidney function in the presence of crizotinib is unknown.