Brief Report: Canadian Cancer Trials Group IND.227: A Phase II randomized study of pembrolizumab in patients with advanced malignant pleural mesothelioma (NCT02784171).

Publication history

Publication stage

Footnotes

Acknowledgement

This trial was supported by grants to CCTG from the Canadian Cancer Society (707213). Merck & Co, Inc provided a study grant and supplied pembrolizumab to CCTG for use at participating sites.

Disclosure Statement of Conflict of Interest

M C Piccirillo : Institutional research support from Roche, Astra Zeneca, Bayer / Honorarium for educational talks - AstraZeneca, Astellas, Pfizer

Q Chu: Adboard and honoraria: Amgen, AnHeart, Astellas, Astra Zeneca, Boehringer Ingelheim, Bristol Meyer Squibb, Eli Lilly, Jazz Pharmaceuticals, Johnson and Johnson, Merck, Novartis, Pfizer, Roche, Takeda. / DSMB: Merck KgaA / Research fundings outside of clinical trials: Astra Zeneca.

P Bradbury: Advisory Board- Abbvie (no financial remuneration); Mirati (no financial remuneration)

F Grosso: personal fees for advisory role, speaker engagements and travel and accommodation expenses from Merck Sharp & Dohme, Novocure, Bristol Meyer Squibb, Boehringer Ingelheim, Pharmamar and Novartis.

M Florescu: Advisory board: AstraZeneca, Roche, Takeda, BMS / Speaker's Bureau: AstraZeneca, Roche, Takeda, BMS

M Mencoboni: Advisory board / speaker fees/travel expenses: Roche, Pfizer, Novartis, Bristol Myers Squibb, Novocure.

J Goffin: Honorarium from AstraZeneca (2022), Eisai (2020), Bristol-Myers Squibb (2020), and Merck (2018).

F Ciardiello: advisory board member for Amgen, Roche, Merck KGaA, Pfizer, Bayer, Servier, MSD, Pierre Fabre, Eisai.

Fabiana Letizia Cecere: (last 2 years): Advisory board / speaker fees/travel expenses: Roche, Novartis, Amgen, Astra Zeneca, Takeda. PI of clinical trials: Pfizer, Merck, Takeda, Astra Zeneca, Novartis, Spectrum, Roche, BMS.

M Vincent: Ad brds/consultancies/invited lectures with almost all major pharma in Canada; Meck, BMS, AZ, Lilly, Amgen, Apobiologix, Boehringer, Roche, Sanofi, Pfizer.

R Ferrara: outside the related manuscript: Advisory Board MSD / Advisory Board Beigene

D Dawe: Advisory board attendance for Merck Canada, Novartis, Jazz Pharmaceuticals, Pfizer, and AstraZeneca, honoraria for education content from Boehringer-Ingelheim and Bristol Myers Squibb, a research grant from AstraZeneca outside the submitted work.

D Hao: institutional funding for 2 MERCK trials at our centre on which I am local PI or co-I

A Morabito: Advisory board member: AstraZeneca, Pfizer, Takeda, MSD, Boehringer / Speaker's Bureau: Roche, AstraZeneca, BMS, MSD, Boehringer, Takeda, Novartis, Lilly, Sanofy.

C Gridelli: honoraria as advisory board member, speaker bureau member or consultant for MSD, BMS, Astra Zeneca, Roche, Amgen , Pfizer , Takeda, Karyopharm, Menarini, Novartis, Sanofi, Eli Lilly , GSK , Boehringer.

L Cavanna: consulting fees: AstraZeneca, and Merck / support for attending meetings and/or travel: Pfizer, Ipsen, and Celgene

N Blais: No conflict in regard to this study. / Industry partnerships: AMGEN, AstraZeneca, Bayer, Beigene, BMS, Eli Lilly, EMD Serono, Ipsen, Merck, Novartis, Pfizer, Roche, Sanofi, Servier, Takeda.

N Leighl: Institutional research support from MSD Canada / Honorarium and/or travel funding for independent CME lectures - MSD

P Wheatley-Price: Advisory board / speaker fees: AstraZeneca, Jazz, Bayer, Novartis, Roche, BMS, Merck, Takeda, EMD Serono, Amgen

H El-Osta: Employee and stockholder in Merck Sharp & Dohme LLC, Rahway, NJ, USA

F Perrone: Personal fees from Bayer, Ipsen, Astra Zeneca, Bristol Myers Squibb, Sandoz, Incyte, Celgene, Pierre Fabre, Janssen Cilag. / Grants to my institution from Astra Zeneca, Bayer, Roche, Merck, Pfizer, Incyte, Sanofi, BioClin, and Tesaro. / All of the above are outside the submitted work.

S A Laurie: honoraria Bayer, Sanofi, Eli Lilly, UpToDate / payments to institution for clinical trials: Merck, BMS

All other authors have no conflict of interests to disclose.

CRediT Statement

Maria Carmela Piccirillo : conceptualisation, writing - review and editing, supervision, project administration

Quincy Chu : conceptualisation, investigation, writing - review and editing

Penelope Bradbury: conceptualisation, investigation, writing - review and editing

Wei Tu: Methodology, formal analysis, writing-review and editing, visualization

Courtney H. Coschi: writing, visualisation.

Federica Grosso: investigation, writing - review and editing

Marie Florescu : investigation, writing - review and editing

Manlio Mencoboni: investigation, writing - review and editing

John R. Goffin: investigation, writing - review and editing

Maria Pagano: investigation, writing - review and editing

Fortunato Ciardiello: investigation, writing - review and editing

Fabiana Letizia Cecere: investigation, writing - review and editing

Mark Vincent: investigation, writing - review and editing

Roberto Ferrara: investigation, writing - review and editing

David E. Dawe: investigation, writing - review and editing

Desiree Hao: investigation, writing - review and editing

Christopher W. Lee: conceptualisation,investigation, writing - review and editing

Alessandro Morabito: investigation, writing - review and editing

Cesare Gridelli: investigation, writing - review and editing

Luigi Cavanna: investigation, writing - review and editing

Mussawar Iqbal: investigation, writing - review and editing

Normand Blais: investigation, writing - review and editing

Natasha B. Leighl: investigation, writing - review and editing

Paul Wheatley-Price: investigation, writing - review and editing

Ming-Sound Tsao: conceptualisation, investigation, writing - review and editing

Francesca Ugo: investigation, writing - review and editing

Hazem El-Osta: writing - review and editing

Piera Gargiulo: writing - review and editing, supervision, project administration

Pierre-Olivier Gaudreau: data curation, investigation, writing - review and editing

Dongsheng Tu: methodology, formal analysis, writing-review and editing

Joana Sederias: data curation, writing-review and editing

Pamela Brown-Walker: writing - review and editing, supervision, project administration, data curation

Francesco Perrone: conceptualisation, writing - review and editing, supervision

Lesley Seymour: conceptualisation, writing, supervision, project administration, funding acquisition, resources

Scott A. Laurie: conceptualisation, investigation, writing

Identification

DOI: https://doi.org/10.1016/j.jtho.2023.02.003

Copyright

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