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Declaration of interests
Caicun Zhou has received payments or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events from Amoy Diagnostics, Boehringer Ingelheim, C-Stone, Hengrui, Innovent Biologics, Lilly China, LUYE Pharma, Merck Sharp & Dohme, Qilu, Roche, Sanofi, and TopAlliance Biosciences Inc.; and is on data safety monitoring boards or advisory boards for Hengrui, Innovent Biologics, Qilu, and TopAlliance Biosciences Inc. Yanfei Tai, Xinjing Ma, and Wei Shi are employees of Hengrui. The remaining authors declare no conflict of interest.
This study was funded by Jiangsu Hengrui Pharmaceuticals, which participated in study design, data collection, and data interpretation. This study was also supported, in part, by grants from the Shanghai Municipal Health Commission Collaborative Innovation Cluster Program (No. 2020CXJQ02) and the National Natural Science Foundation of China (No. 82141101). We are grateful to all patients and their families and all members of the collaborative group. Statistical analyses were provided by PAREXEL International (funded by Hengrui) and medical writing assistance was provided by Dr. Hui Dong for (Medical Writer at Hengrui).
Caicun Zhou: Conceptualization; Data curation; Formal analysis; Funding acquisition; Investigation; Project administration; Resources; Supervision; Validation; Writing - original draft; Writing - review & editing.
Gongyan Chen, Yunchao Huang, Jianying Zhou, LiZhu Lin, Jifeng Feng, Zhehai Wang, Yongqian Shu, Jianhua Shi, Yi Hu, QiMing Wang, Ying Cheng, Fengying Wu, Jianhua Chen, Xiaoyan Lin, Yongsheng Wang, Jianan Huang, Jiuwei Cui, Lejie Cao, Yunpeng Liu, Yiping Zhang, Yueyin Pan, Jun Zhao, LiPing Wang, Jianhua Chang, Qun Chen, Xiubao Ren, Wei Zhang, Yun Fan, Zhiyong He, Jian Fang, Kangsheng Gu, XiaoRong Dong, Faguang Jin, Hongjun Gao, Guangyu An, Cuimin Ding, Xiaodong Jiang, Jianping Xiong, Xiangdong Zhou, Sheng Hu, Ping Lu, Anwen Liu, Shuliang Guo, Jianjin Huang, Chengchu Zhu, Jian Zhao, Beili Gao, Yinglan Chen, Chengping Hu, Jian Zhang, Hongmei Zhang, Hui Zhao: Data curation; Investigation; Project administration; Resources; Writing - review & editing.
Yanfei Tai: Resources; Software; Supervision; Validation; Visualization; Writing - review & editing.
Xinjing Ma: Resources; Software; Supervision; Validation; Writing - review & editing.
Wei Shi: Project administration; Resources; Software; Supervision; Validation; Writing - review & editing.