The study “A Knock-in Mouse Model of Thymoma With the GTF2I L424H Mutation” by He et al.
1
generated a mouse model in which the Gtf2i L424H mutation was conditionally knocked-in in the Foxn1+ thymic epithelial cells and revealed that Gtf2i L424H mutation in the mouse thymus induced thymomas that histologically mirror human-type
B1 and B2 thymomas. I wish to discuss the implications of this finding.- He Y.
- Kim I.K.
- Bian J.
- et al.
A knock-in mouse model of thymoma with the GTF2I L424H mutation [e-pub ahead of print].
J Thorac Oncol.
https://doi.org/10.1016/j.jtho.2022.08.008
Date accessed: September 5, 2022
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References
- A knock-in mouse model of thymoma with the GTF2I L424H mutation [e-pub ahead of print]. J Thorac Oncol.https://doi.org/10.1016/j.jtho.2022.08.008Date accessed: September 5, 2022
- A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors.Nat Genet. 2014; 46: 844-849
- Primary driver mutations in GTF2I specific to the development of thymomas.Cancers (Basel). 2020; 12: 2032
- PD-L1 expression and tumor-infiltrating lymphocytes in thymic epithelial neoplasms.J Clin Med. 2019; 8: 1833
- Sphingomonas and Phenylobacterium as major microbiota in thymic epithelial tumors.J Pers Med. 2021; 11: 1092
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© 2022 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
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- Reply to Dr. Goto’s Letter: “A Thymoma Mouse Model Harboring a Gtf2i L424H Mutation”Journal of Thoracic OncologyVol. 17Issue 11
