Vascular hyperpermeability (leakage) facilitates tumor progression, metastasis, and
limited delivery of therapeutics by fostering a hypoxic tumor microenvironment. Recently,
pharmacological inhibition of vascular leakage enhanced tumor infiltration and activity
of cytotoxic (CD8+) T-cells when used in combination with anti-PD1 blockade. However,
the influence of vascular leakage on the tumor immune contexture and prognostic implications
in human cancer patients remains to be investigated.
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© 2022 Published by Elsevier Inc.
