OA07.03 Association Between Genetic Variation in the ATP-binding Cassette Transporter ABCC10 and nab-PTX Treatment in Japanese Cohort

      ABCC10 is an ATP-binding cassette transporter, which is shown to be involved in the extracellular transport of taxanes. We has reported that differences in rs2125739, one of the single nucleotide polymorphism in ABCC10, affect the cytotoxic effects of docetaxel in lung cancer cell lines and the occurrence of docetaxel side effects in clinical practice. The present study elucidated whether rs2125739 affects the cytotoxicity of paclitaxel (PTX) in lung cancer cell lines. The investigation was conducted for determining the effect of rs2125739 on the efficacy and side effects of nanoparticle albumin-bound PTX (nab-PTX) in clinical practice.
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