Abstract
Introduction
Methods
Results
Conclusions
Keywords
Introduction
Mao W, Zhang X, Guo Z, et al. Association of asbestos exposure with malignant mesothelioma incidence in eastern China [e-pub ahead of print]. JAMA Oncol. https://www.ncbi.nlm.nih.gov/pubmed?term=Association+of+Asbestos+Exposure+With+Malignant+Mesothelioma+Incidence+in+Eastern+China&TransSchema=title&cmd=detailssearch, accessed January 12, 2017.
Materials and Methods
Specimen Collection
Mao W, Zhang X, Guo Z, et al. Association of asbestos exposure with malignant mesothelioma incidence in eastern China [e-pub ahead of print]. JAMA Oncol. https://www.ncbi.nlm.nih.gov/pubmed?term=Association+of+Asbestos+Exposure+With+Malignant+Mesothelioma+Incidence+in+Eastern+China&TransSchema=title&cmd=detailssearch, accessed January 12, 2017.
Pathological Review
IHC
IHC for BAP1 and INO80
Statistical Analyses
Results
Diagnostic Confirmation of MM Related to Tumor Location
Category | n | Total |
---|---|---|
Tumors originally diagnosed as MM | 92 | |
Confirmed diagnoses of MM | 52 | |
Pleura | 12 of 34 | |
Peritoneum | 38 of 56 | |
Tunica vaginalis | 2 of 2 | |
Other, non-MM lesions, pleura | 22 | |
Metastatic carcinomas of lung | 3 | |
Metastatic renal cell carcinoma | 1 | |
Poorly differentiated carcinoma, unknown primary | 6 | |
Thymic carcinoma | 1 | |
Fibrous tumor of pleura | 1 | |
Synovial sarcoma | 1 | |
Chronic pleuritis | 1 | |
Inadequate specimens | 8 | |
Other, non-MM lesions, peritoneum | 18 | |
Metastatic carcinomas, ovary | 4 | |
Solitary fibrous tumor | 2 | |
High grade sarcoma peritoneum | 1 | |
Carcinosarcoma, kidney | 1 | |
Inadequate specimens | 10 |
Sensitivity and Specificity of IHC for Diagnosis of MM
Positive Immunostains | CAM5.2 | % | p Value | Calretinin | % | p Value | WT1 | % | p Value |
---|---|---|---|---|---|---|---|---|---|
MM | 34 of 36 | 94 | 47 of 52 | 90 | 40 of 49 | 82 | |||
Non-MM | 26 of 40 | 65 | <0.01 | 14 of 40 | 35 | <0.0001 | 4 of 40 | 10 | <0.0001 |
Carcinosarcoma | 14 of 16 | 88 | ns | 5 of 16 | 31 | <0.0001 | 1 of 16 | 6 | <0.0001 |
Lung adenocarcinoma | 10 of 10 | 100 | ns | 0 of 10 | 0 | <0.0001 | 0 of 10 | 0 | <0.0001 |
Squamous cell lung cancer | 0 of 10 | 0 | <0.0001 | 7 of 10 | 70 | ns | 0 of 10 | 0 | <0.0001 |
Ovarian adenocarcinoma | 2 of 4 | 50 | <0.05 | 2 of 4 | 50 | ns | 3 of 4 | 75 | ns |
Identification of MM mimickers


BAP1 and INO80 Staining
Histology | BAP1 | ||
---|---|---|---|
n | % | p Value vs. Total MM | |
Total MM | 8 of 22 | 36 | |
Epithelial | 3 of 17 | 18 | |
Biphasic | 3 of 2 | 67 | |
Sarcomatoid | 2 of 2 | 100 | |
Total lung cancers | 20 of 20 | 100 | <0.0001 |
Adenocarcinoma | 10 of 10 | 100 | |
Squamous cell carcinoma | 10 of 10 | 100 | |
Carcinosarcomas | 15 of 15 | 100 | <0.0001 |
Total non-MM | 35 of 35 | 100 | <0.0001 |

Discussion
Mao W, Zhang X, Guo Z, et al. Association of asbestos exposure with malignant mesothelioma incidence in eastern China [e-pub ahead of print]. JAMA Oncol. https://www.ncbi.nlm.nih.gov/pubmed?term=Association+of+Asbestos+Exposure+With+Malignant+Mesothelioma+Incidence+in+Eastern+China&TransSchema=title&cmd=detailssearch, accessed January 12, 2017.
Mao W, Zhang X, Guo Z, et al. Association of asbestos exposure with malignant mesothelioma incidence in eastern China [e-pub ahead of print]. JAMA Oncol. https://www.ncbi.nlm.nih.gov/pubmed?term=Association+of+Asbestos+Exposure+With+Malignant+Mesothelioma+Incidence+in+Eastern+China&TransSchema=title&cmd=detailssearch, accessed January 12, 2017.
Mao W, Zhang X, Guo Z, et al. Association of asbestos exposure with malignant mesothelioma incidence in eastern China [e-pub ahead of print]. JAMA Oncol. https://www.ncbi.nlm.nih.gov/pubmed?term=Association+of+Asbestos+Exposure+With+Malignant+Mesothelioma+Incidence+in+Eastern+China&TransSchema=title&cmd=detailssearch, accessed January 12, 2017.
Mao W, Zhang X, Guo Z, et al. Association of asbestos exposure with malignant mesothelioma incidence in eastern China [e-pub ahead of print]. JAMA Oncol. https://www.ncbi.nlm.nih.gov/pubmed?term=Association+of+Asbestos+Exposure+With+Malignant+Mesothelioma+Incidence+in+Eastern+China&TransSchema=title&cmd=detailssearch, accessed January 12, 2017.
Mao W, Zhang X, Guo Z, et al. Association of asbestos exposure with malignant mesothelioma incidence in eastern China [e-pub ahead of print]. JAMA Oncol. https://www.ncbi.nlm.nih.gov/pubmed?term=Association+of+Asbestos+Exposure+With+Malignant+Mesothelioma+Incidence+in+Eastern+China&TransSchema=title&cmd=detailssearch, accessed January 12, 2017.
Mao W, Zhang X, Guo Z, et al. Association of asbestos exposure with malignant mesothelioma incidence in eastern China [e-pub ahead of print]. JAMA Oncol. https://www.ncbi.nlm.nih.gov/pubmed?term=Association+of+Asbestos+Exposure+With+Malignant+Mesothelioma+Incidence+in+Eastern+China&TransSchema=title&cmd=detailssearch, accessed January 12, 2017.
Acknowledgments
Supplementary Data


- Legends for Supplementary Figures 1 and 2
- Supplementary Table 1
- Supplementary Table 2
- Supplementary Table 3
- Supplementary Table 4
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Article info
Publication history
Footnotes
Drs. Guo and Carbone equally contributed to this work.
Disclosure: Dr. Carbone has a patent pending on BRCA1 associated protein 1 pending and provides consulting expertise on mesothelioma.
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