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Tubular Tumor Growth Along Entire Biopsy Track of Brain Metastasis

      Key Words

      A 58-year-old woman presented with severe fatigue, head-ache, diplopia, and a transient paresis of the left leg.
      Magnetic resonance imaging revealed a solitary right-sided lesion of the cerebral peduncle, without further signs of systemic disease or primary tumor. A stereotactic biopsy of the lesion was performed. Histopathological examination showed adenocarcinoma, presumably of lung origin. The metastasis was treated with stereotactic radiotherapy.
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      FIGURE 1Initial presentation with enhancing right-sided cerebral peduncle lesion (A, white star) with surrounding edema (B, arrowheads). Coronal T1-weighted reconstructions of prebiopsy (C), and postbiopsy images with biopsy trajectory marked (D, short arrows). Follow-up post-radiotherapy image shows a new tubular enhancing lesion located along the biopsy trajectory (E, long arrows) with response of initial lesion (black star).
      Tumor seeding after biopsy is more commonly described in non-central nervous system oncology, but is rarely seen in intracerebral metastatic disease.
      • Karlsson B
      • Ericson K
      • Kihlström L
      • Grane P
      Tumor seeding following stereotactic biopsy of brain metastases. Report of two cases.
      ,
      • Marx T
      • Rainov NG
      • Heidecke V
      • Burkert W
      Secondary tumor formation after stereotactic biopsy for intracerebral metastatic disease.

      REFERENCES

        • Karlsson B
        • Ericson K
        • Kihlström L
        • Grane P
        Tumor seeding following stereotactic biopsy of brain metastases. Report of two cases.
        J Neurosurg. 1997; 87: 327-330
        • Marx T
        • Rainov NG
        • Heidecke V
        • Burkert W
        Secondary tumor formation after stereotactic biopsy for intracerebral metastatic disease.
        Surg Neurol. 2001; 55: 41-45